ApoE isoform-dependent deficits in extinction of contextual fear conditioning
نویسندگان
چکیده
منابع مشابه
Contextual fear conditioning in zebrafish.
Zebrafish are a genetically tractable vertebrate that hold considerable promise for elucidating the molecular basis of behavior. Although numerous recent advances have been made in the ability to precisely manipulate the zebrafish genome, much less is known about many aspects of learning and memory in adult fish. Here, we describe the development of a contextual fear conditioning paradigm using...
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Pavlov (1927/1960) reported that following the conditioning of several stimuli, extinction of one conditioned stimulus (CS) attenuated responding to others that had not undergone direct extinction. However, this secondary extinction effect has not been widely replicated in the contemporary literature. In three conditioned suppression experiments with rats, we further explored the phenomenon. In...
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1 ACKNOWLEDGMENTS I would like to express my deepest gratitude for my thesis adviser, Dr. Dayan Knox, for his patients, guidance, and mentorship in my thesis writing and research efforts. Working in the lab and completing this research project has opened many doors in my life and kick-started my development as a scientist. I would also like to thank all of my lab mates for the time and effort t...
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The locus coeruleus norepinephrine (LC-NE) system plays a broad role in learning and memory. Here we begin with an overview of the LC-NE system. We then consider how both direct and indirect manipulations of the LC-NE system affect cued and contextual aversive learning and memory. We propose that NE dynamically modulates Pavlovian conditioning and extinction, either promoting or impairing learn...
متن کاملPrefrontal neuronal circuits of contextual fear conditioning.
Over the past years, numerous studies have provided a clear understanding of the neuronal circuits and mechanisms involved in the formation, expression and extinction phases of conditioned cued fear memories. Yet, despite a strong clinical interest, a detailed understanding of these memory phases for contextual fear memories is still missing. Besides the well-known role of the hippocampus in en...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2012
ISSN: 1601-1848
DOI: 10.1111/j.1601-183x.2012.00833.x